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Nancy and Kalai are the best. It does not include the preliminary investigations and consultations with the fertility specialist prior to the start of IVF. Success rates in IVF can be misleading and ALLtest saliva antigen test kit 1s Covid 19 Home Test Kit - Pls add bubble wrap, bubble wrap is NOT free & NOT included. Cloudflare Ray ID: 7a29b72a3a1b520e The other two results are inaccurate, but the diagnosis would be euploid or aneuploid. It has been another agonising wait to see if we got any blasts. This can often be an issue in cases of advanced maternal age, where abnormalities become more common. PGS testing can test to see if there are any extra or missing copies of chromosomes in each embryo. As this procedure involves removing a sample of cells, you may question whether it can cause any lasting damage to the embryo. PGD for specific genetic abnormalities requires the development of a "probe". Accu-Chek Accu Chek Performa Blood Glucometer (Glucose Meter) Test Strips 50S, 100S, 150S, 200S / Shipping From Korea . Kloor, who has three usable embryos in Kuala Lumpur, said she cried whenever signs of a border reopening turned out to be a disappointment. How PGS Testing Works in Simple Words. The aim of PGT is to have an unaffected child and in turn avoiding the trauma of terminating the pregnancy. Brands Brands. While she qualifies for the local trial, she has been told that the earliest she can do PGS testing is in December. The cost of PGD or PGS is in addition to your IVF cycle cost. Also known as pre-implantation genetic testing for aneuploidy, PGS is not without risk or ethical implications. They now have a few embryos here, but they want to ship their embryos from Malaysia as a backup. Fertility doctors will then select the embryos of the highest quality for transfer into the uterus. PGD is indeed a boon for couples faced with risk of genetic diseases in their offspring. Kang et al. You can send in your donor requirements like race, nationality, complexion, height, education, etc. A small sample (about 5-10 cells) is typically biopsied from an embryo that has potentially hundreds of cells. We only work with doctors that are aware of the international best practices in IVF and clinics that provide the right treatment at fair prices. It could get more complex with mosaics, like +2, mos[-1], this means that all the cells in the biopsy have trisomy 2, and only some of them have monosomy 1 (so theyre mosaic for monosomy 1). A complex abnormal is one that has 3 or more chromosomal abnormalities. The technology itself also improved and now all chromosomes could be analyzed instead of just a few with FISH. These werent transferred or possibly discarded because they were labelled aneuploid due to the limitations of the technology at the time. PGS testing screens your embryos for any chromosomal abnormalities before transferring the embryo into your uterus. Because my PGS embryos are stuck in Malaysia, Im forced to go through a few more rounds (of IVF) in Singapore.. Selangor DE, Malaysia. In the old days Day 3 (cleavage stage) embryo biopsies were more common. Maternal age does not affect clinical outcomes of vitrified-warmed euploid blastocysts: an Asian Study. If the sex chromosomes are abnormal, there may be physical and developmental problems that may not be diagnosed until puberty, he said. Successfully Trained over 1,000 Software Testers. We encourage you to ask questions and settle all your concerns IVF with PGS in Thailand - starts from around $12,500. The pricing information below is based on the published prices from major centres and pricing information available on blogs and the internet. 115.2 USD bilion. Each chromosome has a short arm (p) and a long arm (q), that can be divided further into bands (like q23.2). The previous photo showed embryonic stem cell therapy instead of an IVF procedure. PGT-M is a genetic test of the embryo for a specific gene defect. The estimated cost of an IVF+PGT cycle including medication is about RM35,000 - RM50,000. We routinely ask patients at the beginning of the treatment whether they want the gender to be revealed.. Terms are highlighted every 3rd time to avoid repetition. Mosaic embryos are a relatively new idea. Invitro fertilization or IVF treatment is the This technique offers an earlier test than alternative ante-natal screening tests which are normally offered between 11-14 weeks of pregnancy. Share; A small sample of each embryo is sent to a genetic testing lab, but your embryos will safely be stored at your IVF . The incidence of chromosomal abnormality (aneuploidy rate) has been validated to increase with women age, Previous Chromosomally abnormal pregnancy, Increase in likelihood having healthy baby, Reduction in time and necessary resources to achieve pregnancy, Autosomal Dominant/ Recessive Polycystic kidney disease & etc. Three of them Alpha IVF, IVF Bridge and TMC Fertility declined to comment. It carries a small risk of damage to the embryo and allows for gender selection. Malaysia, how do you select the one that is just right for you? Its is RM1 for Malaysian and RM100 to RM200 for Non-Malaysian. Number of eggs retrieved. Ever wondered how much does it cost to have an IVF procedure in Malaysia? RTAC certification in compliance with the standards of RTAC International Code of Practice. But extensive research and a commitment to bring the best ART has allowed these doctors to explore factors that can help a couple conceive, hence the high success rates. PGS takes a biopsy cell(s) sample from embryos (refer to Picture 1) and evaluates or test for chromosomal abnormality. in your 20s or early 30s, but research suggests that advanced age can cause Im 41 years old, and I cant keep waiting, said the American expatriate, whose husband is 46 and Korean. However, by submitting your enquiry, you'll hear back from the facility with more details of the pricing. Check here for the full. This included SNP, aCGH and qPCR. The International English Language Testing System (IELTS) is the world's most popular high-stakes English language proficiency test for study, work and migration, with more than three million tests taken in the past year. Available at Sunway Fertility Centre, next generation sequencing (NGS) is the latest, most advanced PGT technology which allows for comprehensive chromosome testing of embryos. No suitable embryos may be found during the procedure. SINGAPORE: After she had a baby boy through in vitro fertilisation (IVF) in Singapore in 2018, health and wellness coach Jamie Alison Kloor and her husband wanted another child. Highly recommend. One cluster of cells will become a fetus, another - a placenta. All 19 Fertility Test Clinics in Malaysia ServiceScore Very Good from 339 users 7.5 Featured DR WEE CLINIC (HORIZON HILLS) 03-9212 1174 ext: 65000 87 Jalan Harimau Tarum Taman Century 80250 Johor Bahru Johor, Malaysia, HORIZON HILLS, ISKANDAR PUTERI, 79100 The RT-PCR test in Sabah and Sarawak is capped at RM200, with RTK-antigen test has a price ceiling of RM80 and RTK-antibody test RM70. Several studies looked at embryo grades and found they do have an impact on euploid success. Garrisi et al. Clinics are nervous transferring them, especially when some cells have trisomy 21, for example! These are some of the highest success rates, not just in Asia but in the world. When carried out by a highly experienced doctor, the risks of this procedure are minimal. So PGS testing was discouraged (Brezina et al. A PGT-A test reveals the number of chromosomes from each embryo. You can check the prices at the hospitals or laboratories that offer this service. PGT enables our embryologist to identify a healthy embryo to be implanted in the mothers womb thus reducing the risk of miscarriage and multiple pregnancy. Couples with PGS-tested embryos stranded overseas now have a glimmer of hope. Sunway Fertility Centre IVF Cost and packages, Fertility Screening for couples > RM 550 per couple, All medications from the start of treatment until pregnancy test, All laboratory charges, including ICSI, Laser-Assisted Hatching and Blastocyst Culture if required, All nursing fees, daycare operative room and recovery room charges, Enfamil vs Enfalac Malaysia : Price and Reviews 2022, Hospital Baby Delivery Rates and Maternity Packages in Malaysia 2022, 10 Best Confinement Centres in KL & Selangor 2022, Top Recommended Gynaecologists in Malaysia 2023, 12 Best Formula Milk for Baby 0-6 months for 2023: Price and Reviews, Difference between Step 1 vs Step 2 vs Step 3 Formula Milk in Malaysia 2022, 7 Best Prenatal Vitamins for Pregnancy in Malaysia 2022, 7 Best Chlorine Free Diapers Malaysia 2022, 12 Best Baby Diapers of 2023 - Prices and Reviews. (2018) present data that shows PGS/PGT-A testing reduces miscarriages, as well as data that shows it doesnt. By day 5, there are around 128 distinctive cells. Travellers are required to undergo Covid-19 testing at BP screening facilities upon arrival in Malaysia to enjoy quarantine-free travel. NiPT bc of the cost and we had done PGS and the screening bc it throws a lot of false positives, especially with age and I'm 35. TERMS & CONDITIONS See more details. Categories . (2015) reviewed several studies: Penzias et al. Local fertility centres must ensure that the embryos are packaged and transported in a way that minimises the risk of contamination, among other requirements, the MOH added. 2019 Ted Fund Donors (2018) looked at about 650 euploid transfers: Note that this is per transfer data. 2016). Embryos that test chromosomally normal (euploid) are then considered for embryo transfer into uterus. Only highly trusted doctors and clinicsImmediate grievance redressal in case you face any problems Counselor support throughoutHighest success rates in the countryLodging, visa, and travel assistanceFull transparency, education, and patient confidenceEasy matching of donor profiles for donor egg IVF. PGS can be performed on fresh embryos at day 3 of development, then they may be implanted on day 5. 22 of these are autosomes (#1-22) and 2 are sex chromosomes (X and Y). But with NGS, 20% mosaic is a mosaic, and not everyone will transfer this (however with emerging research this is likely to change). Pre-implantation Genetic Testing (PGT) screens for genetic conditions that could affect the health of the embryo. The other two said they are keen to appeal. Having a healthy baby is the expectation of each parent. Click to reveal So in these studies, PGS testing did improve rates! We offer the test at 11 locations across the country - Kuala Lumpur, Subang Jaya, Penang, Petaling Jaya, Tawau, Cyberjaya , Ipoh, Johor Bahru, Melaka, Kuching and Kota Kinabalu. Some smaller studies have been done. The doctor and his team were wonderful throughout the entire IVF process. Of the 370 patients recruited for its PGS pilot programme since 2017, only 120 have had their embryos tested. 814 Products . Business Registration No: 938460-K (2011 0101 0321) The cost of PGS /PGT-A testing (and the cost of potentially more cycles in order to get euploid embryos) needs to be weighed against no testing and potentially more transfers/miscarriages by using untested embryos. We have 46 chromosomes 23 come from the egg and 23 from the sperm. PJU 5/22, Kota Damansara, A simple trip to Malaysia for IVF, could turn your infertility into parenthood. The steps for an embryo biopsy are: See that tiny piece? Repromed is the first - and only - clinic in SA to offer Preimplantation Genetic Screening (PGS) testing on site. A technician at work in an IVF centre. All Rights Reserved. At PFCLA, PGD testing costs $6,000 for up to eight embryos. Google Map | Waze Contact Us Tel: +603 6141 6166 Fax: +603 6141 6066 Whatsapp : +6012 5686 290 Email us Operating Hours After 10-12 days you can travel back for egg collection and the rest of the IVF process. I heard that if we go for a PGS test, the likelihood of success might be higher, she said. The two tests conducted on embryos are Preimplantation genetic diagnosis (PGD) and Preimplantation Genetic Screening (PGS). Tortoriello et al. It is a race against time if a pregnancy does not result from all the viable embryos, noted the fertility specialist. For a much more in-depth look at mosaics and their success rates, check out my post on Mosaic embryo. I'm a health specialist Complete embryo analysis of all 24 chromosomes. If must be noted though, PGS is more helpful in women over 35, but in younger patients thesuccess rates of IVF with PGSor without PGS are quite at par. Some couples in Singapore can't access their embryos abroad. This procedure should be considered especially if the woman is above the age of 36 as the age is a risk factor for chromosomal abnormality or have experienced repeated miscarriages. It is possible that inconclusive results may be obtained, in a phenomenon known as mosaicism. This makes it technically simpler and much cheaper to do genetic testing of the Egg Donor's blood sample, as compared to genetic screening of embryos with PGS / PGT-A. CNA Insider spoke to four individuals with PGS-tested embryos in Malaysia. With world leading fertility treatment procedures! Gold price in Malaysia Gold prices per ounce are converted from USD to Malaysian Ringgit according to the latest exchange rates where 1 USD = 4.47 Malaysian Ringgit Gold prices are calculated both per ounce, gram, kilogram and tola and for the most common karats. PGD costs in the US vary from about $3000-$9000 plus all other associated IVF costs. Lee CSS; Low SY; Lim YX; Keith J (Alpha Fertility Centre). Varies depending on number of embryos tested. Show 3 . Claim upto 50% discount on your first consultation at the top fertility clinics in Malaysia with Infertility Aide. 2016) . This efficacy of PGS, has been corroborated by several independentstudiesaround the world. The cost per embryo of PGT-A is about 10,000 to 15,000, which is roughly about 10 to 15 per cent of the IVF cycle.. A mosaic is a mix. PGT-SR = PGT for structural rearragements, A tiny hole is lasered into the zona of the embryo on Day 3 (assisted hatching), By Day 5-7 (it varies), the cells of the embryo poke out of this hole, The cells that are poking out are suctioned and separated using a laser, This biopsied piece is stored in the freezer then sent to another lab for, The biopsied embryo is frozen until results are received and an embryo transfer set up, A monosomy is a deletion of a whole chromosome, A segmental deletion/addition affects only a segment of a chromosome, dup(16) means theres a duplication on chromosome 16, (q23.2-qter) means that this duplication is for the q23.2-qter region. If you want our Health + Ancestry Service plus access to new premium reports and features throughout the year. Does rebiopsy or thaw and biopsy have an impact on success rates? I feel like someone else posted a question similar to this the other day but can't find the post. The cost of IVF in Malaysia is usually based on per cycle basis, which involves series of fertility drugs administration, monitoring the growth of eggs, harvesting and fertilising the eggs and replacing one / two embryos into the uterus. (2018) showed that it occured about 1.5-5% of the time and is dependent on the IVF clinics technical ability. Yap WY; Lim YX; Lee CSS (Alpha Fertility Centre). Mosaic embryos were detected using more sensitive PGS testing technology. Copyright Mediacorp 2023. A large RCT (>600 transfers) byMunne 2019found no difference in miscarriage rates when using untested and tested embryos in good prognosis patients. 2018). This modern technology is an additional process from the traditional IVF process. Every time that happens, you feel youre getting closer, but then youre getting further away.. Self-registration kiosks are available for online purchases. Some of our top Malaysian IVF doctors have established that the transfer of a single good graded euploid blastocyst brings about the highest success ratesupto 82.9%. Recurrent miscarriages may be caused by chromosomal abnormalities in the embryo. This service is not intended for persons residing in the E.U. Im doing (PGS) for medical reasons, said the analyst. The counselors will also answer any additional questions that you may have.Starting on day 2 of your period, you will be given hormonal injections for the next 10-12 days during which you can also walk around the city and go sight-seeing. 2016). You have a history of genetic problems, which may be passed on to the offspring (, You have had several failed fertility treatments, As discussed above, given that PGS is an invasive procedure, there is a slight risk of damage to the embryo during the removal of cells, if not performed by an experienced doctor. Upgraded but still having issues? *. Sunfert has shipped two unscreened embryos to Singapore since the borders closed. Nil. IVF is like an emotional roller-coaster. porterville unified school district human resources; Tags . The follicle growth will be monitored throughout this period though you will NOT be required to visit the clinic every day. Basic IVF procedural fees: $15,400. The pricing is based on the number of embryos to be analysed. The action you just performed triggered the security solution. This involves a small sample of cells being taken from the amniotic fluid, between weeks 16-18 of the pregnancy. These include the adherence to age limits if any donor gametes are used, and the prohibitions against non-medical gender selection and commercial trading of gametes and embryos, the ministry said. This is because the embryos have undergone a genetic screening that is restricted in Singapore. Two of them, including Kloor, have done so and are waiting to hear from the authorities. With age, couples have fewer eggs that can produce babies, diminished egg quality and a greater risk of complications. RM 75.00. Hello,I'm 12 weeks pregnant after transfering a single PGS tested 5-day Blastocyst. IVF with PGS in the UK - starts from around 9,000 Well learn about chromosomal aneuploidy and euploid embryos, how PGS works, how to read PGS testing results, PGS success rates, mosaics and all the controversy! Categories what happened to nicholas dunbar. . Believe it or not, the success of PGS/PGT-A testing is controversial! Disclaimer: Any studies presented here may be contradicted by other studies. They were there to answer all my questions, the costs were outlined very clearly and simply, the staff were very friendly and made the experience as comfortable as possible given the nature. IVF costs are affordable, the IVF clinics we work with have some of the highest success rates, and language is not a problemmost people speak multiple languages and English is widely spoken. PGT-A Preimplantation Genetic Testing for Aneuploidies Helping you have a successful pregnancy and a healthy baby by selecting chromosomally normal embryos. Average cost of first visit consultation is around RM 600 RM 800, which includes basic testing, ultrasound, and consultation with the doctor. PGS does increase the efficiency of IVF by improving embryo selection, thereby increasing the IVF outcomes as follows: Pre-implantation Genetic Diagnosis (PGD) takes a biopsy cell(s) sample from embryos to diagnose embryos for known genetic disorder that both patient and partner are carriers prior to transfer to uterus. For intended parents hoping to test more than eight embryos, you can do so for an additional $250/embryo. The treatments are all customized to your individual requirements. Results in more than 99% of cases. PGD is a type of genetic screening used to detect genes linked to specific diseases. June 16, 2022 | Author The cost of PGS/PGT-A testing (and the cost of potentially more cycles in order to get euploid embryos) needs to be weighed against no testing and potentially more transfers/miscarriages by using untested embryos. Published by at 29, 2022. Sometimes the sample is not loaded properly and the tube is empty (the sample is very small so this does happen), or the sample degrades. PGD can prevent transmission of these this disorder ie, monogenic diseases due to the function of gene is altered by change in the specific sequence, called mutations. He kindly and patiently guided us through the whole process. GENDER SELECTION. Sperm collection: Your partners sperm is collected on the same day and the gametes are fertilized together under controlled conditions in the laboratory. No differences in miscarriage rates in both groups, In one study, 42% vs 69% ongoing pregnancy (no PGS vs, In another study, 48% vs 66% ongoing pregnancy (no PGS vs PGS, mostly single embryo), For >37, live births increased when transferring euploids (58% vs 18%) per transfer, When looking at per retrieval stats, live births decreased with euploids (20% vs 40%), Some studies found no difference between tested and untested, Other studies found PGS testing reduced miscarriage. RM 93.00 . For inconclusive results, a study by Cimadomo et al. PGS is a highly advance technology in modern medical science and accuracy is up to 97% as per the latest report but everyone should know that everything has a limitation and PGS has its own limitations too. Components of Cost Patients typically pay for two components of service. By Day 5 of development (that is, five days after fertilisation), an embryo has divided into multiple cells - and PGS works by removing some of these cells for testing. Petroleum Distillation cri-sab2832-july2009 40 Gasoline Kerosene Lt. Gas Oil Diesel Motor Oils Asphalt. Singapore has had a PGD pilot programme since 2005, and it became a mainstream clinical service this month. RT-PCR tests: RM150 (Peninsula), RM 200 (East Malaysia) RTK-Antigen tests: RM60 . The Ministry of Higher Education Malaysia has endorsed the implementation of the Malay Language Proficiency Test for Non-Malaysians. Fertility medications: $4,000-$8,000. pgs testing cost in malaysia fatal car accident in kentucky 2020. I have 6 embryos frozen I want to PGS test. PGD actually does genetic sequencing and tests for specific hereditary conditions like Huntington's disease. IVF with donor eggsin Malaysia is legally allowed and regulated well. sinners in the hands of an angry god analysis worksheet . You have experienced several failed IVF cycles. But the latter can be overcome by not disclosing the embryos gender to patients. Making changes to your current regimen can lead to . A female has two copies of the X chromosome, and a male has a copy of X and a copy of Y. Chromosomal aneuploidyis when theres any number other than 46. This website is using a security service to protect itself from online attacks. So embryos made from these older oocytes have the same fate. I was just transfered to my OB/GYN who recommended I do NT scan. The selection of normal embryos for transfer, Avoids amniocentesis and its associated risks, Increase the change of having a healthy baby. This occurs when embryos contain both normal and abnormal cells. Any good quality embryos that are left over can be frozen for future use. This is similar to previous years, and shipping costs roughly RM3,000 to RM4,000 (S$960 to S$1,290), he added. You can get some tests done locally, discuss over email, or even schedule an online IVF consultation with one of our doctors, before traveling. An aneuploid embryo that has monosomy 22: An aneuploid embryo that has monosomy 22 and trisomy 10: A segmental aneuploid only has a part the chromosome affected, for example dup(16)(q23.2-qter). So if you have 45, or 49, then thats aneuploid. With improved technology (NGS), we were now able to detect mosaicism. You can go home in 3-4 hours but must not take on any strenuous exercise for the next 2 days. Infertility Aide special: Claim 35% DISCOUNT for your first consultation at the top fertility clinics in Malaysia. Almost every government hospital and clinics in Malaysia provide Covid-19 test. The IELTS results are recognised by more than 11,000 organisations, including educational institutions, employers . Introduction. I daresay for people doing PGS, most arent there to choose the sex but to ensure that the embryos theyll transfer are normal.. PGS decreases risk to couples or individuals with serious inherited disorders of having children affected with same problem. Hysterosalpingography (HSG) is a procedure that uses a special form of X-ray to look at the fallopian tubes and uterus. Aneuploidy is the presence of an abnormal number of chromosomes in a cell such as 45 or 47 chromosomes. I am on my fourth cycle, without ever having seen those two lines. Selangor. Higher quality embryos performed better than lower quality embryos. Before she could try again, COVID-19 hit, and the border between Singapore and Malaysia shut in March last year. Higher pregnancy rates per transfer. Called pre-implantation genetic screening (PGS), it improves the chances of a successful IVF pregnancy. PGT-A typically costs the patient around $5,000 per IVF cycle and equates to 20%-30% of the overall costs of treatment. achieve a pregnancy, but you must have complete information before committing While cost in an important factor, you must not ignore that treatment quality, success rates, the doctors knowledge and capability, and overall clinic standards are more important factors if you want the greatest bang for your buck. More studies are needed. The egg collection process is completed in just about 30 minutes. She has been upfront about this detail, and stressed that she did not undergo PGS to choose her babys gender but because she had lost three frozen embryos during the defrosting process previously. This post will discuss PGS/PGT-A for the most part and Ill use PGS as thats the term most are familiar with. Repromed Fertility Specialists SA Since 1950. Even though it adds to the expense, PGS technology allows the doctors to select the best quality embryo, which in turn raises the chances of successful conception and a healthy pregnancy. PGS minimizes such risks. Besides, the more experienced your doctor, the better equipped they are to handle any risks or complications in your IVF treatment. Example A : a pair of chromosome 21 is normal ; three chromosomes of 21 is Downs Syndrome, Example B : abnormalities of chromosome 23 such as :-. Viral markers to test for HIV, Hepatitis B and C, Syphilis, etc. It is good to take time to plan if you are With so many clinics for IVF in 0 . reviews on the internet can be manipulated. PGS/PGT-A testing is typically recommended for: With advancing age, aneuploidy is more common and can lead to more miscarriages. Munne et al. Older technology like aCGH wasnt as sensitive as the current technology (NGS) and could only detect a mosaic between 40-60% (Maxwell et al. It is used to analyse the chromosomes of the embryos before their transfer into the womb. RM3.50. The Clinic was clean, orderly and welcoming. PGS testing can test to see if there are any extra or missing copies of chromosomes in each embryo. Good For Brain, Heart, Joint Pain & Diabetes. Not just China, patients from Indonesia, Philippines, Fiji, Australia, New Zealand, Vietnam, Bangladesh, United States, UAE, Qatar, and African countries also come to Malaysia to benefit from the advanced IVF infrastructure and excellent facilities. Although there are preimplantation genetic screening pros and cons, this method of genetic testing is a precious one as it: requires to transfer only the healthiest embryo which means a diminished amount of multiple pregnancies; lowers the number of abortions and . PGT-A enables the checking of all 23 sets of chromosomes including X and Y in each embryo so that only normal embryos are selected for transfer into the womb. Performance & security by Cloudflare. Her doctor recommended that she head to Malaysia, where she could undergo an embryo screening procedure to improve her chances of pregnancy. The pregnancy test will be done 15 days later. PGS is a genetic test designed to increase the success rates of IVF. Accu-Chek Instant S Glucose Monitoring Kit & Strips (10 Test Strips + 10 Lancets + Extra 25'S Test Strips) Limited Offer. Gleicher et al. Couples who are at risk of passing a specific gene disorder to your future child should consider PGT-M. Lee et al. Im appreciative of the MOH looking into it and listening to us, she said. So based on this data, its controversial whether or not PGS reduces miscarriages. No Siri Kelulusan: KKLIU 0194/2023 This modern technology is an additional process from the traditional IVF process. The fertilized egg divides into 2 cells, then 4, 8, and so on. * Gold price chart in Malaysia in Malaysian Ringgit Loading. "The price of Covid-19 tests has been capped to ensure that it remains reasonable while the battle against the pandemic rages on," said Baba.