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vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Minor/Significance Unknown. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Minor/Significance Unknown. Avoid or Use Alternate Drug. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Applies only to oral form of both agents. Use Caution/Monitor. Parenteral iron dextran therapy. Controlled studies in pregnant women show no evidence of fetal risk. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. . Applies only to oral form of both agents. Consult your doctor before breast-feeding. Applies only to oral form of both agents. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). Applies only to oral form of both agents. Treatment of anemia due to iron deficiency. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Many patients with kidney disease cannot get enough iron from food and require injections. Applies only to oral form of both agents. Recommended dosing and infusion rates for PI. commonly, these are "preferred" (on formulary) brand drugs. *Administer early during the dialysis session. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Do not mix iron sucrose with other medications or TPN solution. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. 1995 Mar-Apr;11(2):163-8. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. Use Caution/Monitor. vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. Ren Fail. Applies only to oral form of both agents. Minor/Significance Unknown. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Fulminant symptoms may include general paleness, confusion or episodes of passing out. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Applies only to oral form of both agents. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Nutr Clin Pract. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Minor/Significance Unknown. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. The dosage of Venofer is expressed in mg of elemental iron. 1974 Jun;31(6):592-5. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. Administer while the patient is in a reclined or semi-reclined position. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Venofer treatment may be repeated if iron deficiency reoccurs. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Use Caution/Monitor. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Most Medicinal forms Drug class: Iron products. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. 1) Ganzoni AM. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Applies only to oral form of both agents. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. FERAHEME met the predefined criteria for non-inferiority to Venofer . The elemental iron product used is Iron sucrose 20 mg/mL. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. 1) Ganzoni AM. Each mL contains 20 mg of elemental iron. Use Caution/Monitor. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Do not administer Venofer to patients with evidence of iron overload. Applies only to oral form of both agents. Dosing: (a) Divide calculated total cumulate dose . May increase risk of hypotension. Applies only to oral form of both agents. Use Caution/Monitor. Modify Therapy/Monitor Closely. Intravenous iron-dextran: therapeutic and experimental possibilities. These can be input in g/dL, g/L or mmol/L. Am J HealthSyst Pharm 2006;63:731735. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. (3) Known hypersensitivity to Venofer. Canada residents can call a provincial poison control center. The dosage of Venofer is expressed in mg of elemental iron. [. Venofer is given as an infusion into a vein. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Contraindicated. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Individual plans may vary 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Use Caution/Monitor. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Interaction only with oral iron administration. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Applies only to oral form of both agents. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. For additional Safety Information, please see Full Prescribing Information. Below the form there are further instructions on how to use the calculator. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). iron sucrose increases levels of calcium chloride by enhancing GI absorption. Venofer treatment may be repeated if necessary. Slow or stop the infusion if adverse reactions occur. Applies only to oral form of both agents. Where: Medicine concentration Amount of active substance per a given volume of your drug. Fulminant symptoms include confusion, sensation of passing out, paleness. Interaction only with oral iron administration. Use Caution/Monitor. Use Caution/Monitor. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Read our. Corrected Sodium and Effective Osmolality. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Iron Product. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. By clicking send, you acknowledge that you have permission to email the recipient with this information. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. LBW = Lean body weight in kg. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. To view formulary information first create a list of plans. Schweiz Med Wochenschr; 100(7):301-3. Methods. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Accessed: 4/12/2011. Applies only to oral form of both agents. David McAuley, Pharm.D. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Separate dosing of tetracyclines from these products. Iron sucrose: 20 mg/mL. Observed Hb = the patients current hemoglobin in g/dl. Always ask your health care professional for complete information about this product and your specific health needs. iron sucrose, benazepril. If either is present, do not use the liquid. Intravenous iron sucrose: establishing a safe dose. Generic name: IRON SUCROSE 20mg in 1mL If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. The primary endpoint was the proportion of patients with . Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. an automated flowchart approach. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Use Caution/Monitor. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. official version of the modified score here. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Separate dosing of tetracyclines from these products. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. J Lab Clin Med; 111(5):566-70. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Minor/Significance Unknown. Applies only to oral form of both agents. Due Date form Ultrasound Report. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Applies only to oral form of both agents. Applies only to oral form of both agents. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Use Caution/Monitor. 1970; 100(7):301-3. Applies only to oral form of both agents. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Venofer [package insert]. Use Caution/Monitor. Compare formulary status to other drugs in the same class. Applies only to oral form of both agents. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. 1970;100(7):301303. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Where C= concentration of For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Applies only to oral form of both agents. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). In the text below the tool there is more information on how the iron deficit is calculated. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. 1982;13(4):309-21. Administer Venofer early during the dialysis session (generally within the first hour). Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. commonly, these are "non-preferred" brand drugs. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. The dosage of Venofer is expressed in mg of elemental iron. We have found the lower dose to be better tolerated in the second half of gestation. It can be expressed in mg per ml. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Drug Des Devel Ther; 5: 5160. Applies only to oral form of both agents. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Deferasirox chelates iron. Use Caution/Monitor. Use Caution/Monitor. Max Dose. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Discuss the risks and benefits with your doctor.This medication passes into breast milk. Avoid or Use Alternate Drug. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. We'll do this entirely for free, as long as the calculator has applications for women's health. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Each mL contains 20 mg of elemental iron. Avoid or Use Alternate Drug. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Do not administer Venofer to patients with iron overload. Use Caution/Monitor. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. This information does not assure that this product is safe, effective, or appropriate for you. Use Caution/Monitor. Applies only to oral form of both agents. Copyright 1993-2021 Venofer must only be administered intravenously either by slow injection or by infusion. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Use Caution/Monitor. ONE DOSE. Applies only to oral form of both agents. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. This cost includes the fee charged by the pharmacy. 2015: 763576. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Chandler G, Harchowel J, Macdougall I. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. . Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Step 2: Calculation and administration of the maximum individual iron dose(s): . This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Use Caution/Monitor. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. A: Generally acceptable. Pediatric Patients (2 Years of Age and Older). Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Avoid or Use Alternate Drug. Each mL contains 20 mg of elemental iron. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Accessed: 4/12/2011. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes.