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sneezing. It is safe to drink alcohol in moderation if you have COPD and use Trelegy Ellipta. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Trelegy Ellipta. Through half-life, you may easily know that dosages of Tren is needed after 2-3 days to keep the levels maintain and stable. This can cause you to breathe in too much medication, which may be harmful to you. Trelegy Ellipta costs significantly more than Symbicort. It's a brand-name prescription drug used for COPD or asthma in. Here are some examples of other drugs that may be used to treat asthma. When you open the tray that contains Trelegy Ellipta, write the date that you opened it on the label of the inhaler. If you develop symptoms of thrush, be sure to see your doctor. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Symbicort, or with both drugs (when taken individually). Do not use Trelegy Ellipta if you have a severe allergy to milk proteins (like lactose). You can prevent thrush from developing by always rinsing your mouth after you take your dose of Trelegy Ellipta. Pulmonologist just switched me to Trelegy. Certain antidepressant medications can interact with Trelegy Ellipta. That means with a half-life of 5 days, it will likely take 27.5 days-almost a whole month-for the body to clear this drug. May 2019. Trelegy Ellipta interacts with about 500 medications, and most of these interactions are moderate in severity, but may still have an important clinical impact. They may have alternate medications that dont interact with Trelegy Ellipta. COPD is a long-term disease in which the airways and air sacs inside the lungs become damaged or blocked, leading to difficulty breathing. The word Ellipta refers to the specific type of inhaler that contains the drug. unpleasant or unusual taste in your mouth. They can advise you on the best way to feed your child. Seek emergency medical treatment or call 911 if your breathing problems get worse quickly. Be sure to write the date that you open the inhaler on the label. Read and follow all patient instructions provided with the inhaler device. You should always consult your doctor or other healthcare professional before taking any medication. How long does Trelegy stay in your system? If you have questions about how to treat sudden breathing problems while taking Trelegy Ellipta, talk with your doctor. Talk to your provider right away if you experience blurry vision, eye discomfort, or other changes in their vision after using Trelegy Ellipta. In COPD patients: Upper respiratory tract infection, a runny nose and sore throat, pneumonia, taste disturbances, bronchitis, constipation, thrush (yeast infection) in your mouth and throat, painful and frequent urination (signs of a urinary tract infection), headache, nausea, vomiting, and diarrhea, back pain, mouth and throat pain, joint pain, cough, flu, hoarseness, and inflammation of the sinuses. The following information describes dosages that are commonly used or recommended. The doses are delivered in premeasured puffs. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Before taking Trelegy Ellipta, talk with your doctor about your health history. It can even detect nicotine for . Trelegy Ellipta and Symbicort are both brand-name drugs. Fluticasone is an inhaled steroid medication. There are a total of 30 doses in each Trelegy Ellipta inhaler. Trelegy Ellipta is also approved for the once-daily maintenance (long-term) treatment of asthma in adults. Trelegy Ellipta may cause headaches. Trelegy Ellipta contains three different drugs (fluticasone, umeclidinium, and vilanterol), so you usually wont need to take another maintenance medication along with it. It is a maintenance medicine for long-term use to help prevent flare-ups. However, beta-blockers can block the effects of Trelegy Ellipta and cause the medication to not work properly. As with all medications, the cost of Trelegy Ellipta can vary. For information about this, see the Trelegy Ellipta use with other drugs section below. For more information and to find out if youre eligible for support, call 888-825-5249 or visit the program website. Instead, youll use a rescue inhaler for sudden trouble breathing. If you have sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). Rinse your mouth with water without swallowing after use to help prevent thrush (a yeast infection in your mouth and throat area). When you get Trelegy Ellipta from the pharmacy, the pharmacist will add an expiration date to the label on the box. What is TRELEGY ELLIPTA used for? Never take two doses at once to try to make up for a missed dose. Last updated on Oct 11, 2022. Like Breo Ellipta (above), the drug Symbicort has uses similar to those of Trelegy Ellipta. Strong cytochrome P450 3A4 inhibitors, like ketoconazole, an antifungal medicine, Monoamine oxidase inhibitors, a class of antidepressants, Anticholinergics, for example, cold or allergy medicines (Benadryl and others), FDA Approves Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) for the Treatment of Asthma. If you miss a dose of Trelegy Ellipta, take it as soon as you remember. This list does not contain all drugs that may interact with Trelegy Ellipta. Symbicort comes as a metered dose inhaler. The FDA website provides several useful tips on medication disposal. ; Weakened immune system and increased chance of getting infections How quickly this medicine works for you will depend upon your previous treatments, your symptoms and lung function, and tolerance. The drug isnt meant to be used for sudden breathing problems caused by asthma. The medication is in a powder form that you breathe into your lungs. Trelegy Ellipta is meant to be used as a long-term treatment. Ask your doctor or pharmacist if you do not understand these instructions. Below is a list of medications that can interact with Trelegy Ellipta. Fluticasone furoate is metabolized mainly by cytochrome P450 (CYP) 3A4. It should be stored in a dry place and kept away from sunlight and heat. Can you take Trelegy and Symbicort together? It is the fast acting steroid and usually has a half-life around 2-3 days. The drugs are fluticasone, umeclidinium, and vilanterol. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. For patients who do not respond adequately to Trelegy Ellipta 100/62.5/25 mcg once daily, increasing the dose to Trelegy Ellipta 200/62.5/25 mcg once daily may provide additional improvement in asthma control. For more information about this, see the Trelegy Ellipta use with other drugs section below. (An active ingredient is the part of the medication that makes it work. The inhaler isnt reusable, and you cant refill it. Lipson DA, Barnhart F, Brealey N, et al. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. If you develop back pain from taking Trelegy Ellipta, talk with your doctor. Trelegy Ellipta contains lactose as a major excipient. Copyright 1996-2023 Drugs.com. Review the full product information for Trelegy Ellipta here and discuss this information with your doctor or other health care provider. Trelegy Ellipta is approved in two different strengths for asthma, both given once daily. Examples of tricyclic antidepressants include: If youre taking an antidepressant, talk with your doctor before you start using Trelegy Ellipta. Here are some examples of other drugs that may be used to treat chronic obstructive pulmonary disease (COPD). Heart failure: Could a low sodium diet sometimes do more harm than good? Trelegy Ellipta was studied in over 10,000 patients with symptomatic chronic obstructive pulmonary disease (COPD) and a history of prior exacerbations (flare-ups). If theyre more severe or dont go away, talk with your doctor or pharmacist. So if youre taking Spiriva, youll need to stop using it before you start Trelegy Ellipta treatment. The official half-life of sildenafil is 3-4 hours after an oral dose in the range of 25mg - 200mg. stomach flu. With emphysema, your lungs are damaged and have trouble passing air in and out. The FDA-approved strength for treatment of both COPD and asthma in adults is fluticasone furoate 100 mcg / umeclidinium 62.5 mcg / vilanterol 25mcg. Clinical trials have shown that when a LABA is used in combination with an ICS, using the LABA does not increase the risk of asthma-related death and hospitalization. Medically reviewed by Leigh Ann Anderson, PharmD. The insurance company will review the information and let you and your doctor know if your plan will cover Trelegy Ellipta. It combines an inhaled corticosteroid (ICS), a long-acting muscarinic antagonist (LAMA) and long-acting beta2-adrenergic agonist (LABA). How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, chronic obstructive pulmonary disease (COPD), forced expiratory volume in 1 second (FEV1), Trelegy Ellipta expiration, storage, and disposal, Professional information for Trelegy Ellipta. So in theory, its possible for Trelegy Ellipta to cause you to gain weight. Instead, to treat a flare-up, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). If youre having sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). Do NOT take two doses at the same time. In clinical trials, 4% to 9%* of people who took Trelegy Ellipta developed headaches. Based on a survey for secondary outcomes, Trelegy also improved patients health-related quality of life when compared to Breo, which included items such as daily symptoms, daily activities and perceived well-being. There were no reports of weight gain in this study. Trelegy Ellipta is not used as a fast-acting inhaler for the relief of acute breathing emergencies. urinary tract infection *. Drugs.com. It is mainly eliminated via the fecal route after an intravenous dose is given. It reaches steady state within 14 days of daily dosing. Because Trelegy Ellipta can also affect your heart rhythm, you shouldnt take these medications while using Trelegy Ellipta. Keep all medicines out of the reach of children and pets. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It should be taken every day to treat your condition over a long-term period. Urine tests can detect cannabis in the urine for approximately 3-30 days after use. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. If you have glaucoma, Trelegy Ellipta may worsen your disease. The drug was studied and shown to be safe and effective for long-term use in people with either COPD or asthma. If you have any questions about eating certain foods with Trelegy Ellipta, talk with your doctor. N Engl J Med. fluticasone, an inhaled corticosteroid that lowers inflammation and swelling in the lung airways, vilanterol, a long-acting beta-agonist (LABA) bronchodilator that relaxes the airway muscles to help open airways. It should be stored in the unopened foil tray until it is ready for use. ** This strength of Trelegy Ellipta is abbreviated as 200/62.5/25 mcg. It is not known if the medicines in Trelegy Ellipta will harm your unborn baby or pass into your breast milk and harm your baby. Available for Android and iOS devices. Trelegy Ellipta is a combination medication thats used to treat symptoms of chronic obstructive pulmonary disease (COPD). They can discuss rescue inhaler options with you. Umeclidinium is minimally orally absorbed. Beta-blockers are common medications that help decrease blood pressure and steady your heart rhythm. If you miss your dose of Trelegy, take it as soon as you remember. Follow your doctor's instructions about tapering your dose. Benzodiazepines and MDMA generally flag a urine test for up to 4 days after last dose. If you drink alcohol, talk with your doctor whether its safe for you to continue drinking while youre taking Trelegy Ellipta. Is the ketogenic diet right for autoimmune conditions? Trelegy Ellipta can interact with several other medications. If you need a fast-acting inhaler like albuterol, contact your health care provider right away, as you should always have one on hand. Its Cmax occurs about 5 to 15 minutes post-dose. How long a medication remains good can depend on many factors, including how and where you store the medication. The drug can also make a certain type of glaucoma called narrow-angle glaucoma worse. Trelegy Ellipta shouldnt be used later in pregnancy (at or after 28 weeks) or during labor unless recommended by your doctor. For example, it can differ whether you're taking an inhaled medication such as Advair (fluticasone and salmeterol) or an oral corticosteroid (e.g., prednisone ). Its metabolites have minimal activity. Trelegy Ellipta isnt approved to treat sudden trouble breathing. In 2017, the Food and Drug Administration (FDA) approved Trelegy Ellipta to treat COPD. Serious side effects from Trelegy Ellipta arent common, but they can occur. Symptoms of thrush include mouth pain or white patches in the mouth. Trelegy is the brand name of the medication inside the inhaler. Using more than the recommended dosage of Trelegy Ellipta can lead to serious side effects. Therefore, an overdose isnt likely to occur. Results showed a 25% reduction in the annual rate of flare-ups vs. Anoro, and a 15% reduction in the annual rate of flare-ups vs. Breo. More recently, in 2020, the drug was approved to treat asthma. Ask your healthcare provider if you are not sure if this applies to you. Tell them about all prescription, over-the-counter, and other drugs you take. A steroid medication's half-life determines how long it circulates in your body. Seek emergency treatment or call 911 if your breathing problems get worse quickly. And too much cortisol can lead to weight gain. They may be able to recommend ways to help prevent headaches from occurring. umeclidinium, a long-acting muscarinic antagonist (LAMA), an anticholinergic bronchodilator that helps to block muscle tightening around your airways to improve breathing. The study showed that people who took Trelegy Ellipta were able to force out 97 mL more air in 1 second than people who took Breo Ellipta. If you do not have a fast-acting inhaler, call your doctor for a prescription. pain or tenderness around the eyes and cheekbones. They can tell you about other medications that may work well for you. Vilanterol is a long-acting beta2-agonist (LABA). It is usually oxidized via hydroxylation or O-dealkylation and then conjugated via glucuronidation to produce metabolites. ICS medicines work by decreasing lung inflammation (swelling) that can cause breathing problems. These foil strips hold Trelegy Elliptas active drugs as follows: Note: After you inhale a dose of Trelegy Ellipta, be sure to rinse your mouth with water and spit out the water without swallowing. frequent urge to urinate. Studies also showed that treatment with Trelegy Ellipta decreased the risk of COPD exacerbations (flare-ups of COPD symptoms). Instead, youll use a rescue inhaler for sudden trouble breathing. They arent meant to be used for sudden breathing problems caused by asthma. They may be able to recommend a different diuretic. Its important to note that Trelegy Ellipta is meant to be used over time to control COPD symptoms. For more information about COPD and asthma, see the Trelegy Ellipta for COPD and Trelegy Ellipta for asthma sections above. Most inhaled steroids have a beneficial effect for 12 hours. If you miss a dose of Trelegy Ellipta, take it as soon as you remember, and then take your next dose at your usual time. Lung function improvements (change from baseline in trough forced expiratory volume over one second [FEV1] at month 12) were also significant in the study. If you would like to report to the FDA a side effect youve had with Trelegy Ellipta, you can do so through MedWatch. diarrhea. Only second day but extremely short of breath. For information about this, see the Trelegy Ellipta use with other drugs section below. Trelegy Ellipta comes as an inhaler. You should use Trelegy Ellipta at the same time each day. This is compared with 3% to 7%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). Keep Trelegy Ellipta in a dry place, away from sunlight and heat. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. So if you have a milk allergy, you may have an allergic reaction to the lactose in Trelegy Ellipta. Trelegy Ellipta is indicated for use in adults with either chronic obstructive pulmonary disease (COPD) or asthma. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. In comparison, back pain only occurred in about 1% to 4%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). In the trials, Trelegy Ellipta was compared with a combination of placebo plus two of its three drugs: fluticasone and vilanterol. Each inhaler has two foil strips inside it that contain blisters of the medication. Once the counter on the inhaler reads 0 (meaning that no doses are remaining), you can dispose of Trelegy Ellipta. It works by activating adenyl cyclase, which then catalyzes a reaction from adenosine triphosphate (ATP) to cyclic 3,5,adenosine monophosphate (cyclic AMP). Symbicort has two active drug ingredients in it: budesonide and formoterol. Umeclidinium has a half-life of about 11 hours. Trelegy Ellipta should be discarded in the trash 6 weeks after first use OR when the counter reads 0 (which means you are out of medicine), whichever occurs first. Trelegy Ellipta has been evaluated in the treatment of asthma or COPD in studies ranging from 12- to 52-weeks long. Some saliva tests have detected . Trelegy Ellipta is an inhaled medication thats used for long-term treatment of chronic obstructive pulmonary disease (COPD) and asthma. These conditions affect your airways, making it hard to breathe sometimes. Marijuana stays in the system a bit longer, with amounts being detectable for between 1 and 7 days after last use. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Breo Ellipta, or with both drugs (when taken individually). Sherm 3 years ago. If you are in the donut hole coverage phase, your copay could vary between $5-$713. Medically reviewed by Leigh Ann Anderson, PharmD. This medication works mainly in your lungs and isnt absorbed well into your body. Can diet help improve depression symptoms? For information about this, see the Trelegy Ellipta use with other drugs section below. Steroids can increase your level of cortisol, which is a hormone that has effects on your metabolism. Step 1: Prepare a dose Wait to open the cover until you are ready to take your dose. Instead, youll use a rescue inhaler for sudden trouble breathing. They can review any possible drug interactions for you. TRELEGY in COPD: data from two 12-week studies and a 52-week long-term study Across two 12-week studies in subjects with COPD, the most commonly reported adverse reactions with 1% incidence and more common than BREO were: Long-term safety data: 52-week study in subjects with COPD Only remove the inhaler from the unopened tray when ready to use. * This is a partial list of mild side effects from Trelegy Ellipta. Accessed Oct. 21 at doi:10.1056/NEJMoa1713901, Trelegy Ellipta [Prescribing Information]. Trelegy Ellipta is a combination medication thats used to treat asthma. You shouldnt take Trelegy Ellipta with other anticholinergic medications. It is not known if this medicine is safe and effective in children younger than 18 years of age. Compared to Breo (fluticasone furoate / vilanterol) 100/25 mcg, Trelegy Ellipta 100/62.5/25 mcg once daily demonstrated a 110 mL significant improvement in FEV1 over a 24 week period. This medication is taken as one inhalation. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Its important that even if you dont feel or taste your dose, you dont take another dose. Trelegy Ellipta is used in adults whose disease is not controlled well enough with a combin ation of inhaled medicines consisting of a long-acting beta-2 agonist plus either a corticosteroid or a long- For more information about what these drugs do, see the How Trelegy Ellipta works section below. There have been reports of serious allergic reactions, including anaphylaxis, when people with milk allergies take Trelegy Ellipta. This is an inhaler that dispenses the drug as a spray, which you breathe into your lungs. Trelegy is only inhaled once per day because the medication effect lasts for at least 24 hours. For asthma, the recommended dosage of Trelegy is one inhalation (puff) of Trelegy Ellipta once a day. The studies also showed that asthma exacerbations (flare-ups of asthma symptoms) occurred in: Other drugs are available that can treat your condition. Higher FEV1s show better lung function, while lower FEV1s show poorer lung function. In clinical trials, Trelegy Ellipta was effective in treating COPD. Breo is a brand-name prescription medication. Taking these medications together may increase your risk for side effects. All rights reserved. Sharing this information can help you avoid potential interactions. Trelegy Ellipta also contains umeclidinium. According to GoodRx, if you are in the post-deductible phase, your copay could range between $0-$713. This is not all the information you need to know about Trelegy Ellipta for safe and effective use. The medication is in a powder form that you breathe into your lungs. And this can cause the level of Trelegy Ellipta in your body to be too high, increasing your risk for side effects. Trelegy works by lowering lung inflammation and relaxing the airways in patients with either asthma or COPD. Accessed Oct. 21, 2020 at https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Trelegy/pdf/TRELEGY-ELLIPTA-PI-PIL-IFU.PDF, FDA Approves Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) for the Treatment of Asthma. Trelegy Ellipta is NOT used as a fast-acting rescue inhaler for sudden breathing problems. In studies, Trelegy has shown a positive effect on breathing tests (FEV1) with the first dose, but it may take several weeks or longer for your overall symptoms to improve in COPD or asthma. Tell your doctor if you have glaucoma or elevated eye pressure before you start treatment. This may help decrease your risk of getting oral thrush, which is a fungal infection in your mouth. For chronic obstructive pulmonary disease (COPD), the recommended dosage of Trelegy is one inhalation (puff) of Trelegy Ellipta 100/62.5/25 mcg once each day. Instead, youll use a rescue inhaler for sudden trouble breathing. Cardiovascular health: Insomnia linked to greater risk of heart attack. Trelegy Ellipta is a combination medication that contains three drugs: fluticasone, umeclidinium, and vilanterol. The following lists contain some of the key side effects that may occur while taking Trelegy Ellipta. Improvements in lung function have also been seen when Trelegy was compared to Symbicort Turbuhaler in 24-week studies or with Symbicort plus Spiriva in 12 week studies. In the trials, Trelegy Ellipta was compared with two of its three drugs: fluticasone and vilanterol. Trelegy Ellipta is also contraindicated in people with allergies to any of the ingredients in the medication, including fluticasone furoate, umeclidinium, vilanterol, lactose monohydrate, and magnesium stearate. A medication timer may be useful, too. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Theres also a video on the manufacturers website that shows you the correct way to take Trelegy Ellipta. One study showed that FEV1 in people who took Trelegy Ellipta was 59 mL higher than it was in people who took fluticasone and vilanterol. This is because both of these medications have a drug called an anticholinergic in them. If you take umeclidinium with another anticholinergic medication, the drugs effects can combine and increase your risk for side effects. These medications can be used for many different types of infections, such as bacterial, viral, or fungal. They may be able to suggest a different treatment. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. After an intravenous dose, 58% is excreted in the feces and 22% is excreted in the urine. Trelegy Ellipta and Symbicort both contain medications that work in similar ways to treat your COPD. Your doctor or pharmacist may also be able to recommend ways to help prevent a thrush infection from occurring in the future. If you miss a dose of Trelegy Ellipta, take it as soon as you remember, and then take your next dose at your usual time. GlaxoSmithKline LLC, the manufacturer of Trelegy Ellipta, offers a coupon for the medication. Higher FEV1s show better lung function, while lower FEV1s show poorer lung function. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Maximum recommended dosage is 1 inhalation of TRELEGY 200 once daily. Lactose is an inactive ingredient in Trelegy Ellipta that helps the medication reach your lungs. 2018;378(18):1671-1680. Before you start treatment, tell your doctor if you have: heart or liver problems, high blood pressure, diabetes, seizures or epilepsy, thyroid problems, osteoporosis (weak or brittle bones), an immune system problem, or glaucoma (including increased pressure in your eye, cataracts, blurred vision, or other changes in vision). Primary treatment of status asthmaticus or other acute episodes of COPD or asthma where intensive measures are required. Breo comes in a powder. You can find an updated list of ingredients at the end of the manufacturers patient information. If your potassium level gets too low, you can have heart problems such as an irregular heart rhythm (a heartbeat thats too fast, too slow, or uneven). If youre breastfeeding, talk with your doctor before taking Trelegy Ellipta. The lost dose will still be in the inhaler, but its not possible for you to take two doses with one puff. Accessed Oct. 4, 2022 at, Trelegy Ellipta [Prescribing Information]. If you and your doctor determine that Trelegy Ellipta is safe and effective for you, youll likely take it long term. This medication is taken as one inhalation (puff) of Trelegy Ellipta once each day. Theres no human data available on whether the active drugs in Trelegy Ellipta pass into breast milk or how the drug may affect a child. COPD is a long-term disease in which the airways and air sacs inside the lungs become damaged or blocked, leading to difficulty breathing. Its available only as a brand-name medication. Patients with severe hypersensitivity . The drug isnt meant to be used for sudden breathing problems caused by COPD. Three active drug ingredients make up Trelegy Ellipta: fluticasone furoate, umeclidinium, and vilanterol. Its not currently available in generic form. Their recommendation will depend on how severe your asthma is and whether youve used other asthma treatments in the past. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. These lists contain examples of serious side effects that can occur with Trelegy Ellipta, with Symbicort, or with both drugs (when taken individually). This mild side effect is explained in more detail below in Side effect details.. nausea. Other combination medications that may be used to treat COPD include: Other medications that may be used to treat COPD include: Note: Trelegy Ellipta and the alternative drugs listed here are meant to be used over time to control COPD symptoms. In animal studies, umeclidinium was seen in the breast milk of mothers who were given the drug. Brand-name medications usually cost more than generics. Ask your doctor what other treatments are better choices for you. Its important to note that Trelegy Ellipta contains a powder form of lactose (a sugar in milk). Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD. In another clinical study, Trelegy Ellipta was compared with the two active ingredients in Breo Ellipta. Here are answers to some frequently asked questions about Trelegy Ellipta. Trelegy Ellipta (generic name: fluticasone furoate / umeclidinium / vilanterol) is an inhaler for asthma or COPD and must be used daily to be effective. If youre taking a beta-blocker, tell your doctor before you start using Trelegy Ellipta. For this condition, your doctor may prescribe either Trelegy Ellipta 100/62.5/25 mcg or Trelegy Ellipta 200/62.5/25 mcg. Trelegy Ellipta and Symbicort are both approved to treat COPD and asthma in adults. It contains these three active drugs that help relieve breathing symptoms of COPD and asthma: Trelegy Ellipta comes as an inhaler.